| Day | Home team | Score/Time | Away team | |
|---|---|---|---|---|
| Friday | ||||
|
FT
|
Monterrey | 1 - 0 | América | View events |
| Day | Home team | Score/Time | Away team | ||
|---|---|---|---|---|---|
| Thursday | |||||
|
FT
|
Monterrey | 1 - 0 | Cruz Azul | View events | |
| Friday | |||||
|
FT
|
Cruz Azul | 1 - 4 | Monterrey | View events | |
| Aggr. | Cruz Azul | 1 - 5 | Monterrey | ||
| Friday | |||||
|
FT
|
América | 2 - 0 | Philadelphia Union | View events | |
| Thursday | |||||
|
FT
|
Philadelphia Union | 0 - 2 | América | View events | |
| Aggr. | Philadelphia Union | 0 - 4 | América | ||
| Day | Home team | Score/Time | Away team | ||
|---|---|---|---|---|---|
| Wednesday | |||||
|
FT
|
Atlanta United | 0 - 3 | Philadelphia Union | View events | |
| Wednesday | |||||
|
FT
|
Philadelphia Union | 1 - 1 | Atlanta United | View events | |
| Aggr. | Philadelphia Union | 4 - 1 | Atlanta United | ||
| Wednesday | |||||
|
FT
|
Toronto | 1 - 3 | Cruz Azul | View events | |
| Wednesday | |||||
|
FT
|
Cruz Azul | 1 - 0 | Toronto | View events | |
| Aggr. | Cruz Azul | 4 - 1 | Toronto | ||
| Thursday | |||||
|
FT
|
Columbus Crew | 2 - 2 | Monterrey | View events | |
| Thursday | |||||
|
FT
|
Monterrey | 3 - 0 | Columbus Crew | View events | |
| Aggr. | Monterrey | 5 - 2 | Columbus Crew | ||
| Thursday | |||||
|
FT
|
Portland Timbers | 1 - 1 | América | View events | |
| Thursday | |||||
|
FT
|
América | 3 - 1 | Portland Timbers | View events | |
| Aggr. | América | 4 - 2 | Portland Timbers | ||
